Dentale Stammzellen: Grundlagen und Perspektiven

Aktueller Stand der dentalen Stammzellforschung

Nachwachsende „dritte Zähne“ sind ein Wunschtraum seit Menschengedenken und werden auch von Patienten öfters ins Gespräch gebracht. Die Stammzellforschung, die heute in den Medien zu den häufig diskutierten Themen der Biomedizin gehört, hat solchen Wünschen neuen Auftrieb gegeben. „Züchtung von Zähnen“, „neue Zähne durch Stammzellen“ sind Schlagzeilen, die man so oder ähnlich immer mehr in Printmedien oder im Internet lesen kann. In der Zahnärzteschaft sind die Meinungen zu diesen Themen wahrscheinlich ähnlich breit gefächert wie in der Gesamtbevölkerung und schwanken zwischen Ablehnung aus Angst vor einem möglichen Niedergang von Prothetik, Zahnerhaltung oder Implantologie und einer Euphorie über neue „biologische“ regenerative Methoden.

• Literatur

• 1 Inanç B, Elçin YM. Stem cells in tooth tissue regeneration – Challenges and limitations. Stem Cell Rev and Rep 2011; 7: 683-692
• 2 Mitsiadis TA, Papgerakis P. Regenerated teeth: the future of tooth replacement?. Regen Med 2011; 6: 135-139
• 3 Yildirim S, Fu SY, Kim K et al. Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine. Int J Oral Sci 2011; 3: 107-116
• 4 Kawashima N. Characterisation of dental pulp stem cells: A new horizon for tissue regeneration?. Arch Oral Biol 2012; 57: 1439-1458
• 5 Mao JJ, Prockop DJ. Stem cells in the face: tooth regeneration and beyond. Cell Stem Cell 2012; 11: 291-301
• 6 Sedgley CM, Botero TM. Dental stem cells and their sources. Dent Clin N Am 2012; 56: 549-561
• 7 Hipp J, Atala A. Sources of stem cells for regenerative medicine. Stem Cell Rev 2008; 4: 3-11
• 8 Nichols J, Smith A. The origin and identity of embryonic stem cells. Development 2011; 138: 3-8
• 9 Drews K, Jozefzuk J, Prigione A et al. Human induced pluripotent stem cells – from mechanisms to clinical applications. J Mol Med 2012; 90: 735-745
• 10 Wagers AJ. The stem cell niche in regenerative medicine. Cell Stem Cell 2012; 10: 362-369
• 11 Bieback K, Wuchter P, Besser D et al. Mesenchymal stromal cells (MSCs): science and f(r)iction. J Mol Med 2012; 90: 773-782
• 12 Prockop DJ, Oh JY. Medical therapies with adult stem/progenitor cells (MSCs): A backward journey from dramatic results In vivo to the cellular and molecular explanations. J Cell Biochem 2012; 113: 1460-1469
• 13 Hynes K, Menicanin D, Gronthos S et al. Clinical utility of stem cells for periodontal regeneration. Peridontology 2000 2012; 59: 203-227
• 14 Ibarretxe G, Crende O, Aurrekoetxa M et al. Neural crest stem cells from dental tissues: A new hope for dental and neural regeneration. Stem Cells Int 2012; 2012: 103503
• 15 Kaltschmidt B, Kaltschmidt C, Widera D. Adult craniofacial stem cells: Sources and relation to the neural crest. Stem Cell Rev and Rep 2012; 8: 658-671
• 16 Nakahara T. Potential feasibility of dental stem cells for regenerative therapies: stem cell transplantation and whole-tooth engineering. Odontology 2011; 99: 105-111
• 17 Schmalz G, Galler KM. Tissue injury and pulp regeneration. J Dent Res 2011; 90: 828-829
• 18 Hunag GTJ. Dental pulp and dentin tissue engineering and regeneration: advancement and challenge. Front Biosci 2011; E3: 788-800
• 19 Machado E, Fernandes MH, de Sousa Gomes P. Dental stem cells for craniofacial tissue engineering. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2012; 113: 728-733
• 20 Kim RH, Mehrazarin S, Kang MK. Therapeutic potential of mesenchymal stem cells for oral and systemic diseases. Dent Clin N Am 2012; 56: 651-675
• 21 Keeve PL, Dittmar T, Gassmann G et al. Characterization and analysis of migration patterns of dentospheres derived from periodontal tissue and the palate. J Peridontol Res 2012;
• 22 Honda MJ, Imaizumi M, Tsuchiya S et al. Dental follicle stem cells and tissue engineering. J Oral Sci 2010; 52: 541-552
• 23 Khojasteh A, Behnia H, Dashti SG et al. Current trends in mesenchymal stem cell application in bone augmentation: A review of the literature. J Oral Maxillofac Surg 2012; 70: 972-982
• 24 Nie H, Lee CH, Tan J et al. Musculoskeletal tissue engineering by endogenous stem/progenitor cells. Cell Tissue Res 2012; 347: 665-676
• 25 Yen AHH, Sharpe PT. Stem cells and tooth tissue engineering. Cell Tiss Res 2008; 331: 359-372
• 26 Ikeda E, Morita R, Nakao K. Full functional bioengineered tooth replacement as an organ replacement therapy. PNAS 2009; 106: 13475-13480
• 27 Jussila M, Thesleff I. Signaling networks regulating tooth organogenesis and regeneration, and the specification of dental mesenchymal and epithelial cell lineages. Cold Spring Harb Perspect Biol 2012; 4: a008425
• 28 Liu L, Rando TA. Manifestations and mechanisms of stem cell aging. J Cell Biol 2011; 193: 257-266
• 29 Krishnamurthy S, Nör JE. Head and neck cancer stem cells. J Dent Res 2012; 91: 334-340
• 30 Yu Z, Pestell TG, Lisanti MP et al. Cancer stem cells. Int J Biochem Cell Biol 2012; 44: 2144-2151
• 31 Rossomando EF. Prosthodontics and implants: from xenodontics to biodontics. Compend Contin Educ Dent 2007; 28: 418-420